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What is Liposomal CBD? How about Nano CBD? Is it better than regular CBD?

Good question. Before we get into it, let’s talk about liposomes. Without getting into a biochemistry lesson, what are they in a nutshell?
 
Pharmaceutical-grade liposomes can provide the power of intravenous therapy in the convenience of oral supplements.
 
Sounds impressive, doesn’t it? An improved drug delivery system with greater bioavailability means more drug available to your body. In theory, this works wonderful, and works especially well with cancer treatments that cost thousands of dollars.
 
 

Does it work for CBD?

 
Absolutely. There’s no question that correctly-produced liposomal products provide improved absorption of nutrients, including applications for CBD.
 
Great! Sign me up!
 
Not so fast. This is exciting in theory, but the critical step needed to make this happen is in the manufacturing process. Many companies produce liposomes that are unstable and too large for the body to optimally absorb and use.
 
 

For liposomal supplement delivery, size matters.

 
Smaller liposomal spheres and emulsions are the result of refined chemistry and high-shear equipment, which come at a significant production cost. Any inconsistencies will leave larger-sized spheres that are not as bioavailable, leaving the consumer with a less effective, yet high-cost product.
 
Manufacturers of liposome products have no valid oversight or proof to verify purity and sphere size in each batch of CBD.
 
 

Who regulates these supplements and over-the-counter products?

 
The manufacturer is responsible for evaluating the safety and labeling of their products.
 
 

Multiple Challenges

 
  1. Manufacturing issues (large, inconsistent particle size, poor ingredients)
  2. Instability of some products
  3. Higher cost
  4. No guarantee of quality or labeling, you must take the claims at face value
  5. Liposomal CBD shows promise in the future, but current manufacturing and testing processes don’t support a cost effective, verifiable product that consumers can rely on.
 
Nano CBD is a CBD molecule coated with small particles, like liposomes or lipid nanoparticles (LNPs), that stabilize the CBD and can improve drug delivery in our blood.
 
The theory is it allows the CBD to stay in the body for a longer time and to slowly release the intact CBD into the targeted tissue. A person who consumes nano CBD as opposed to regular CBD may feel the effects more quickly.
 
However, adequate human data on CBD nanotechnology is nonexistent, although cellular data shows promise. A 2017 study reported an increase in bioavailability of oral nano CBD compared to CBD in a rat model.
 
 
Nanoemulsion theoretically produces CBD easier for the body to absorb, but that doesn’t mean it’s actually easier to absorb. In addition, the nanoparticles also spend about half as much time in your system.
 
Any benefit from nano CBD might be comparable to taking a higher dose to get the same effect, and assuming that the CBD product in the bottle is exactly what’s reported on the label, this might be a deal breaker when genuine nano CBD or liposomal formulations cost significantly more than quality CBD suspended in an oil carrier.
 
Like liposomal CBD, current manufacturing and testing processes don’t support a cost effective, verifiable product that consumers can rely on. Ultimately, the decision rests with the consumer.

References 

https://pubmed.ncbi.nlm.nih.gov/27895934/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818067/