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The Untold Truth How Cannabis Affects Everyone Differently


Our genes determine how we respond to different compounds, including the active compounds of cannabis (THC and CBD) [1].

Scientists estimate that around 20% of the U.S. adult population has a unique genetic mutation resulting in increased levels of their body’s endocannabinoids.

If you’re in that 20%, you’ll be less reactive to the effects of THC and CBD in general since your body already produces high concentrations of its own cannabinoids.

Unique Biochemistry

Each of us is unique in our biochemistry. 

Whenever we introduce compounds to the body like cannabinoids, they interact slightly differently depending on some of the biochemical reactions taking place in the body.

This isn’t limited to cannabis. It happens with nearly every chemical that enters the body. 

That’s because our biochemistry changes over time and is affected by genetics, lifestyle, diet, habits, exposure to stress, along with other medications and supplements, medical conditions, and more.

Your biochemistry can change the way cannabis affects you at any given moment.

Your Gender

Men and women can respond to CBD differently. Women could be more sensitive to CBD according to some research. In the video below, Dr. Vandrey  discusses psychoactive effects with CBD and THC. Well With Sativa does not carry vaporized products or inhaled products, and many of our products contain 0% THC for those not wanting the THC component. We support all ongoing research with regard to CBD as this paves the way to better understanding CBD and its health benefits.


CBD doesn’t cause users to build a tolerance, as indicated by one study from 2011 [3]. However, some CBD users report tolerance formation after consistently taking high doses of CBD over 1,500 mg daily.




We recommend having no expectation for how CBD will make you feel. The best thing to do is use it for at least a week, then take a step back to see if there is any change or improvement. Different dosages can also be adjusted based on input from your doctor. Once you’ve gained a better understanding of how you react to CBD, you can use it according to your individual needs.


  1. Tunbridge, E. M. et al. (2015). Genetic Moderation of the Effects of Cannabis: Catechol-O-methyltransferase (COMT) Affects the Impact of Delta9-tetrahydrocannabinol (THC) on Working Memory Performance But Not on the Occurrence of Psychotic Experiences. Journal of Psychopharmacology, 29(11), 1146-1151.
  2. Farguhar, C.E., Breivogel, C.S., Gamage, T.F., Gay, E.A., Thomas, B.F., Craft, R.M., Wiley, J.L. (2019) Sex, THC, and Hormones: Effects on Density and Sensitivity of CB1 Cannabinoid Receptors in Rats. Drug and Alcohol Dependance, 194, 20-27.
  3. Bergamashi, M.M., Queiroz Costa, R.H., Crippa, J.A., and Zuardi, A.W. (2011). Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent. Current drug Safety, 6.
  4. Bhattacharyya, S. et al. (2010). Opposite Effects of Delta-9-tetrahydrocannabinol on Human Brain Function and Psychopathology. Neuropsychopharmacology, 35, 764-774.
  5. Jones, R.T. (1971). Tetrahydrocannabinol and the Marijuana-induced Social “High,” or the Effects of the Mind on Marijuana.